Anti-UMPS (aa 381-479) polyclonal antibody

Species Reactivity

Human

Immunogen

UMPS (NP_000364, 381 a.a. ~ 479 a.a) partial recombinant protein with GST tag. The sequence is DYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIG KRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLG

Conjugate

Alternative Names

UMPS; uridine monophosphate synthetase; OPRT; uridine 5-monophosphate synthase; OPRTase; OMPdecase; UMP synthase; orotate phosphoribosyltransferase; orotidine 5-phosphate decarboxylase;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a uridine 5-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

Pathway

Drug metabolism - other enzymes; Fluoropyrimidine Activity; Metabolism of nucleotides; Pyrimidine metabolism