Anti-UGGT1 monoclonal antibody, clone FQS6216

Antibody Isotype

IgG

Clone

FQS6216

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in Human UGGT (Q9NYU2).

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IHC-P: 1/100 - 1/250;

Alternative Names

UGGT1; UDP-glucose glycoprotein glucosyltransferase 1; UDP glucose ceramide glucosyltransferase like 1 , UGCGL1; UDP-glucose:glycoprotein glucosyltransferase 1; HUGT1; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-lik

Entrez Gene ID

UniProt ID

Antigen Description

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.

Pathway

Asparagine N-linked glycosylation, organism-specific biosystem; Calnexin/calreticulin cycle, organism-specific biosystem; ER Quality Control Compartment (ERQC), organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; N-glycan trimming in the ER and Calnexin/Calreticulin cycle, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem;