Anti-UBR1 (aa 2-100) polyclonal antibody

Species Reactivity

Human

Immunogen

UBR1 (NP_777576, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. The sequence is ADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEK QEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCG

Conjugate

Alternative Names

UBR1; ubiquitin protein ligase E3 component n-recognin 1; JBS; E3 ubiquitin-protein ligase UBR1; E3a ligase; N-recognin-1; ubiquitin ligase E3 alpha-I; ubiquitin-protein ligase E3-alpha; ubiquitin-protein ligase E3-alpha-1; ubiquitin-protein ligase E3-alp

Entrez Gene ID

UniProt ID

Antigen Description

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Pathway

Adaptive Immune System; Proteasome degradation; presentation;