Rabbit Anti-Human UBB Polyclonal antibody

Mutant ubiquitin (UBB+1), a product of "molecular misreading," is toxic to cells because its ubiquitinated form inhibits the proteasome, contributing to accumulation of misfolded proteins and their ensuing toxicity. The authors demonstrate in 10 sporadic inclusion body myositis (s-IBM) muscle biopsies that UBB+1 is accumulated in aggregates containing amyloid-beta and phosphorylated-tau. In s-IBM, UBB+1 may be pathogenic by inhibiting proteasome, thereby promoting accumulation of cytotoxic misfolded amyloid-beta and phosphorylated-tau.

Regulation and control of thermally activated building systems (TABS). Thermally activated building systems (TABS) are becoming increasingly important in terms of energy efficient cooling and heating of buildings. In practice, however regulation and control of such systems often causes problems. Started five years ago with the aim of getting to grips with these problems, the TABS Control research project was completed in early 2009. The project yielded the following results: various models and simulation programs for TABS; performance-bound calculations for regulating zones; a range of zone regulation/control strategies for planners to choose from, including good solutions for automatic switching between heating and cooling, for pulsed operation of the zone pump and for room temperature control,, the implementation of a subset of these strategies as standard solutions in a Siemens building automation system, laboratory tests on these strategies; a new procedure for the integrated planning of TABS and their regulation/control (referred to as UBB planning procedure - Unknown But Bounded); an Excel planning tool, guidelines on selecting the hydraulic switching topology; a method for operation optimization,- the theoretical basis for the new integrated planning procedure and the new regulation/control strategies; a patent application.