Anti-TUBG1 monoclonal antibody (DCABH-378)

Mouse Anti-Human TUBG1 monoclonal antibody for IHC-P, ICC, ELISA, WB, IHC-Fr, ICC/IF, IHC-FoFr Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
HUV-99
Species Reactivity
Mouse, Rat, Chicken, Hamster, Cow, Dog, Human, Xenopus laevis, Indian Muntjac
Immunogen
Synthetic peptide conjugated to KLH, corresponding to N-terminal amino acids 38-53 of gamma Tubulin.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/10000;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TUBG1; tubulin, gamma 1; TUBG, tubulin, gamma polypeptide; tubulin gamma-1 chain; TUBGCP1; gamma-1-tubulin
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TUBG1 (Tubulin Gamma 1) is a Protein Coding gene. Diseases associated with TUBG1 include cortical dysplasia, complex, with other brain malformations 4 and subcortical band heterotopia. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2. This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7.
Antigen Description
Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients. Note=The disease is caused by mutations affecting the gene represented in this entry. The function about TUBG1 antigen include GTP binding; GTPase activity; nucleotide binding; protein binding; structural constituent of cytoskeleton.
Pathway
Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem.

Citations


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References


Caracciolo, V; D'Agostino, L; et al. Differential Expression and Cellular Distribution of gamma-Tubulin and beta III-Tubulin in Medulloblastomas and Human Medulloblastoma Cell Lines. JOURNAL OF CELLULAR PHYSIOLOGY 223:519-529(2010).
LIU, B; JOSHI, HC; et al. GAMMA-TUBULIN IN ARABIDOPSIS - GENE SEQUENCE, IMMUNOBLOT, AND IMMUNOFLUORESCENCE STUDIES. PLANT CELL 6:303-314(1994).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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