Anti-TUBA1A polyclonal antibody (DPABH-19459)

Rabbit anti-Human TUBA1A (aa 37-286) polyclonal antibody for WB, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Recombinant fragment, corresponding to a region within amino acids 37-286 of Human TUBA1A (NP_006000).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/3000; ICC/IF: 1/100 - 1/200.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TUBA1A; tubulin, alpha 1a; tubulin alpha-1A chain; B ALPHA 1; FLJ25113; TUBA3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TUBA1A (Tubulin Alpha 1a) is a Protein Coding gene. Diseases associated with TUBA1A include lissencephaly 3 and lissencephaly due to tuba1a mutation. Among its related pathways are Transport to the Golgi and subsequent modification and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA4B. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Antigen Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Lissencephaly 3 (LIS3) [MIM:611603]: A classic type lissencephaly associated with psychomotor retardation and seizures. Features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem. Note=The disease is caused by mutations affecting the gene represented in this entry. Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1A gene. 0The function about TUBA1A antigen include GTP binding; GTPase activity; nucleotide binding; protein domain specific binding; structural molecule activity.
Pathway
Cell Cycle; Cell Cycle, Mitotic; Centrosome maturation; Chaperonin-mediated protein folding; Cooperation of Prefoldin and TriC/CCTin actin and tubulin folding; Formation of tubulin folding intermediates by CCT/TriC; G2/M Transition.

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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Cushion, TD; Paciorkowski, AR; et al. De Novo Mutations in the Beta-Tubulin Gene TUBB2A Cause Simplified Gyral Patterning and Infantile-Onset Epilepsy. AMERICAN JOURNAL OF HUMAN GENETICS 94:634-641(2014).
Mochida, GH; et al. Genetics and Biology of Microcephaly and Lissencephaly. SEMINARS IN PEDIATRIC NEUROLOGY 16:120-126(2009).

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