Anti-TRIOBP polyclonal antibody (DPABH-03420)

Rabbit Anti-Human TRIOBP (aa 1833-2061) polyclonal antibody for WB, IHC-P, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Human
Immunogen
Recombinant fragment, corresponding to a region within amino acids 1833 and 2061 of Human TRIOBP (Uniprot: Q9H2D6).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000; ICC/IF: 1/100 - 1/1000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TRIOBP; TRIO and F-actin binding protein; DFNB28; TRIO and F-actin-binding protein; HRIHFB2122; KIAA1662
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TRIOBP (TRIO And F-Actin Binding Protein) is a Protein Coding gene. Diseases associated with TRIOBP include deafness, autosomal recessive 28 and dfnb28 nonsyndromic hearing loss and deafness. GO annotations related to this gene include ubiquitin protein ligase binding and GTP-Rho binding. An important paralog of this gene is MPRIP. This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).
Antigen Description
TRIOBP is a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. This trio binding protein also associates with F actin and stabilizes F actin structures. Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations affecting the gene represented in this entry. TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene. 0The function about TRIOBP antigen include GTP-Rho binding; actin binding; myosin II binding; ubiquitin protein ligase binding.

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References


Shahin, H; Walsh, T; et al. Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. AMERICAN JOURNAL OF HUMAN GENETICS 78:144-152(2006).
Bradshaw, NJ; Bader, V; et al. Aggregation of the Protein TRIOBP-1 and Its Potential Relevance to Schizophrenia. PLOS ONE 9:-(2014).

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