Anti-TRIM37 (aa 865-964) polyclonal antibody

Species Reactivity

Human

Immunogen

TRIM37 (NP_056109, 865 a.a. ~ 964 a.a) partial recombinant protein with GST tag. The sequence is GHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGMSSDSDIECDTENEEQEEHTSVGGF HDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR

Conjugate

Alternative Names

TRIM37; tripartite motif containing 37; MUL; POB1; TEF3; E3 ubiquitin-protein ligase TRIM37; mulibrey nanism protein; RING-B-box-coiled-coil protein; tripartite motif-containing protein 37;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.

Pathway

Adaptive Immune System; Proteasome degradation; presentation; Ubiquitin mediated proteolysis.