TRIM21 (NP_003132, 68 a.a. ~ 175 a.a) partial recombinant protein with GST tag. The sequence is QLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVP LEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQK
Conjugate
Unconjugated
Target
Alternative Names
TRIM21; tripartite motif containing 21; SSA; RO52; SSA1; RNF81; Ro/SSA; E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antig
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Pathway
Adaptive Immune System; Proteasome degradation; presentation; Immune System
Citations
Publication ()
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