Anti-Thyroid Peroxidase monoclonal antibody (DCABH-20034)

Mouse Anti-Human Thyroid Peroxidase monoclonal antibody for ELISA, CLIA, RIA, IHC, WB

Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Species Reactivity
Human
Immunogen
Human thyroid peroxidase.
Conjugate
Unconjugated

Target


Alternative Names
TPO; thyroid peroxidase; TPX; thyroperoxidase; thyroid microsomal antigen; MSA
Entrez Gene ID
UniProt ID

Product Background


Pathway
Amine-derived hormones, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem;

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Evaluation of the structure, autoimmunity, and functions of the thyroid gland in familial Mediterranean fever patients

ARCHIVES OF ENDOCRINOLOGY METABOLISM

Authors: Yilmaz, Muge Ozsan; Celik, Muhammet Murat; Keles, Fatma Ozturk; Ozcan, Oguzhan

Objective: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder that is frequently seen in the eastern Mediterranean region. The thyroid gland can be affected in FMF patients through autoimmunity or amyloidosis. Here, we aimed to evaluate the structure and functions of the thyroid gland in addition to possible autoimmunity in FMF patients. Subjects and methods: The study was conducted by the Endocrinology and Metabolism and Internal Medicine Departments.Thirty FMF patients and 30 age and gender-matched healthy controls were enrolled in the study. Free thyroxin (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), and anti-thyroid peroxidase (anti-TPO) autoantibodies were investigated. Detailed thyroid grayscale and Doppler Ultrasonography examinations and shear-wave elastosonography (SWE) were performed in the patient and control groups. Results: Anti-TPO was detected in 24% (n = 7) of the patients. On the grayscale US, mean thyroid volumes were similar between the FMF and the control groups (p > 0.05). By Doppler US, thyroid vascularity observed was detected in 10.3% (n = 3) of the patients. SWE revealed that the mean velocity value of right vs. left lobe in the patient group was 1.77 +/- 0.45 m/s and 1.95 +/- 0.51 m/s, respectively. Compared to the control group, the mean velocity values were significantly higher in the right (p = 0.004) and left (p = 0.01) lobes of the patient group. The mean stiffness value in the patient group was also significantly higher in the right and left lobes [10.13 +/- 5.65 kPa (p = 0.005) and 12.24 +/- 6.17 kPa (p = 0.02), respectively]. Conclusion: Recognizing the complications of FMF early in the course of the disease is as important as the early diagnosis of the disorder. Based on this, thyroid functions and changes in its structure should be evaluated carefully for early diagnosis of a possible coexisting thyroid disorder.

Ru0.05Ce0.95O2-y deposited on functionalized alumina as a smart catalyst for propane oxidation

APPLIED CATALYSIS B-ENVIRONMENTAL

Authors: Ledwa, Karolina A.; Kepinski, Leszek; Ptak, Maciej; Szukiewicz, Rafal

In this work, we synthesized and characterized a novel catalyst containing Ru(0.05)Ce(0.)(95)O(2-y )nanoparticles (2-5 nm) deposited on the functionalized gamma-Al2O3 support. The catalyst was studied with a wide range of ex-situ (STEM-HAADF/EDS, TEM, BET, Raman spectroscopy, XRD) and in situ methods (TPR-TPO, XPS with in situ thermal treatments) in order to determine its behavior during the successive reduction-oxidation treatments. The system shows good reversibility of the noble metal ex-solution on the particles' surface and its redispersion in the cerium oxide structure, with excellent stability of nanoparticles' morphology. The catalyst was active in the propane oxidation at 210 degrees C and could be reactivated by heating in hydrogen at 500 degrees C.

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