Anti-TP53 monoclonal antibody, clone QBc2731

Name: Anti-TP53 monoclonal antibody, clone QBc2731
SKU: DCABH-5155
Rating: 5 (1 reviews)

Mouse Anti-Mouse TP53 monoclonal antibody for ICC, IHC-Fr, IHC-P, IP

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG2a

Clone

QBc2731

Species Reactivity

Mouse; Rat; Cow; Human

Immunogen

Full length protein (Mouse).

Conjugate

Unconjugated

Applications

Application Notes

ICC: 1 - 20 μg/ml; IP: 1 μg/ml.

Target

Alternative Names

TRP53; transformation related protein 53; cellular tumor antigen p53; tumor supressor p53; tumor suppressor p53; p53 cellular tumor antigen; bbl; bfy; bhy; p44; p53; Tp53;

Entrez Gene ID

22059

UniProt ID

P02340

Product Background

Antigen Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Pathway

Activation of BH3-only proteins, organism-specific biosystem; Activation of NOXA and translocation to mitochondria, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem;

Citations