p53 protein acts as a tumor suppressor in many tumor types and induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Defects in TP53 are found in many types of cancers.
Pathway
AMPK signaling; Activation of NOXA and translocation to mitochondria; Alzheimers Disease; Amyotrophic lateral sclerosis (ALS)
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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HAMMEL, PR; BEUVON, FX; et al. IMMUNOCHEMICAL EVIDENCE OF A MUTATED P53 PROTEIN EXPRESSED IN HUMAN COLORECTAL ADENOCARCINOMA. GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE 15:529-535(1991).
Zent, CS; Burack, WR; et al. Mutations in chronic lymphocytic leukemia and how they affect therapy choice: focus on NOTCH1, SF3B1, and TP53. HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM :119-124(2014).
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COA
Certificate of Analysis
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