TP53 belongs to the p53 proteins family. It is ubiquitously expressed, acts as a tumor suppressor in many tumor types and induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Defects in TP53 are a cause of esophageal cancer (ESCR), lung cancer (LNCR), adrenocortical carcinoma (ADCC), choroid plexus papilloma (CPLPA) and so on.
Pathway
AMPK signaling; Activation of NOXA and translocation to mitochondria; Alzheimers Disease; Amyotrophic lateral sclerosis (ALS)
Citations
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