Anti-TNFSF8 monoclonal antibody (CABT-47132RM)

Rat Anti-Mouse TNFSF8 monoclonal antibody for FC; IF

Additional Formats Available

Specifications


Host Species
Rat
Antibody Isotype
IgG2b
Clone
RM153
Species Reactivity
Mouse
Immunogen
Mouse CD153/CHO cells
Conjugate
Unconjugated

Applications


Application Notes
Flow Cyt: 1/10 - 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TNFSF8; tumor necrosis factor (ligand) superfamily, member 8; CD153; Cd30l; CD30LG; tumor necrosis factor ligand superfamily member 8
Entrez Gene ID
UniProt ID
P32972

Product Background


Pathway
Cytokine-cytokine receptor interaction;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Genetic polymorphisms of EPHX1, Gsk3 beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma

LEUKEMIA

Authors: Durie, B. G. M.; Van Ness, B.; Ramos, C.; Stephens, O.; Haznadar, M.; Hoering, A.; Haessler, J.; Katz, M. S.; Mundy, G. R.; Kyle, R. A.; Morgan, G. J.; Crowley, J.; Barlogie, B.; Shaughnessy, J., Jr.

Bone disease in myeloma occurs as a result of complex interactions between myeloma cells and the bone marrow microenvironment. A custom-built DNA single nucleotide polymorphism (SNP) chip containing 3404 SNPs was used to test genomic DNA from myeloma patients classified by the extent of bone disease. Correlations identified with a Total Therapy 2 (TT2) (Arkansas) data set were validated with Eastern Cooperative Oncology Group (ECOG) and Southwest Oncology Group (SWOG) data sets. Univariate correlates with bone disease included: EPHX1, IGF1R, IL-4 and Gsk3 beta. SNP signatures were linked to the number of bone lesions, log(2) DKK-1 myeloma cell expression levels and patient survival. Using stepwise multivariate regression analysis, the following SNPs: EPHX1 (P = 0.0026); log(2) DKK-1 expression (P = 0.0046); serum lactic dehydrogenase (LDH) (P = 0.0074); Gsk3 beta (P = 0.02) and TNFSF8 (P = 0.04) were linked to bone disease. This assessment of genetic polymorphisms identifies SNPs with both potential biological relevance and utility in prognostic models of myeloma bone disease. Leukemia (2009) 23, 1913-1919; doi: 10.1038/leu.2009.129; published online 6 August 2009

A novel role for reciprocal CD30-CD30L signaling in the cross-talk between natural killer and dendritic cells

BIOLOGICAL CHEMISTRY

Authors: Simhadri, Vijaya Lakshmi; Hansen, Hinrich P.; Simhadri, Venkateswara R.; Reiners, Katrin S.; Bessler, Martina; Engert, Andreas; von Strandmann, Elke Pogge

The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely undefined. Here, we provide evidence for a contribution of CD30 (TNFRSF8) and its ligand CD30L (TNFSF8) expressed on NK cells and DCs, respectively. We demonstrate that CD30-mediated engagement of CD30L induced cytokine secretion from immature DCs via the mitogen-activated protein kinase pathway. Moreover, CD30L engagement promoted differentiation to mature DCs. On the contrary, the engagement of CD30 on NK cells resulted in an NF-kappa B-dependent release of TNF-alpha/IFN-gamma. These data uncover a novel and unexpected role for CD30/CD30L that contributes to proinflammatory immune responses.

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