Rabbit Anti-HumanTNFSF13 (center region) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

APRIL antibody was raised against a synthetic peptide corresponding to amino acids near the center of human APRIL.

Conjugate

Alternative Names

TNFSF13; tumor necrosis factor (ligand) superfamily, member 13; APRIL; CD256; TALL2; ZTNF2; TALL-2; TRDL-1; UNQ383/PRO715; tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand; tumor necrosis factor-like protein ZTNF2; tumor

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Pathway

Cytokine-cytokine receptor interaction; Gene Expression; HuR stabilizes mRNA; Intestinal immune network for IgA production; Regulation of mRNA stability by proteins that bind AU-rich elements; Rheumatoid arthritis; Spinal Cord Injury