Anti-TNFRSF1B monoclonal antibody, clone 91N3

Antibody Isotype

IgG1

Clone

91N3

Species Reactivity

Rat

Immunogen

This information is considered to be commercially sensitive

Conjugate

Alternative Names

TNFRSF1B; tumor necrosis factor receptor superfamily, member 1b; tumor necrosis factor receptor superfamily member 1B; p75; TNF-R2; TNF-RII; TNFR-II; p80 TNF-alpha receptor; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II; Tnfr2;

Entrez Gene ID

UniProt ID

Antigen Description

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Pathway

Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;