Anti-TNFRSF19 monoclonal antibody, clone 3H5

Antibody Isotype

IgG1

Clone

3H5

Species Reactivity

Human

Immunogen

TNFRSF19 (AAH47321.1, 30 a.a. ~ 119 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

TNFRSF19; tumor necrosis factor receptor superfamily, member 19; tumor necrosis factor receptor superfamily member 19; TAJ; TAJ alpha; toxicity and JNK inducer; TRADE; TROY; TAJ-alpha;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Pathway

Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;