TACI, transmembrane activator and CAML-interactor, is a member of the TNF receptor superfamily (TNFRSF). Within the TNFRSF, it shares the highest homology with BCMA. TACI and BCMA both bind APRIL and BLyS/BAFF, members of the TNF superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Human and mouse TACI share 54% amino acid sequence identity.
Pathway
Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Primary immunodeficiency; Syndecan-2-mediated signaling events; Syndecan-4-mediated signaling events;
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