Anti-TNFRSF10C monoclonal antibody, clone 00006

Antibody Isotype

IgG1

Clone

00006

Species Reactivity

Human

Immunogen

Mouse myeloma cell line NS0-derived recombinant human TRAIL R3/TNFRSF10C. Ala26-Ala221 Accession Number O14798

Conjugate

Application Notes

Western Blot: 1 μg/mL; Immunohistochemistry: 8-25 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4113 - DPABY-648

Alternative Names

TNFRSF10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR; tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; cytotoxic TRAIL recept

Entrez Gene ID

UniProt ID

Antigen Description

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.

Pathway

Apoptosis; Apoptosis Modulation and Signaling; Cytokine-cytokine receptor interaction; Direct p53 effectors; Influenza A; Measles; Natural killer cell mediated cytotoxicity; TRAIL signaling pathway;