Rabbit Anti-Human TMEM33 (a.a. 177-247) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat

Immunogen

Recombinant human TMEM33 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 177-247 aa of BC000948

Conjugate

Application Notes

WB: 1:1000-1:6000

General Notes

This product (Catalog No. DPABH-08735) is a rabbit-derived polyclonal antibody raised against human TMEM33, targeting the amino acid region 177–247 of the protein. This antibody exhibits cross-reactivity with Human TMEM33 from mouse and rat. It has been affinity purified by Protein A. TMEM33 (transmembrane protein 33), also known as DB83. It is expected to be located in endoplasmic reticulum membrane and nucleus envelope. The protein is widely expressed in prostate cancer and several cancer cell lines (at protein level). And expressed at higher levels in endocrine-resistant breast cancer cells as compared to endocrine-sensitive breast cancer cells. It is also expressed at higher levels in early recurrence breast cancer tissues as compared to non-recurrent breast tumors. The calculated molecular weight of TMEM33 is 28 kDa. It is suggest that TMEM33 has a potency to suppress the membrane-shaping activity of reticulons, thereby regulating the tubular structure of ER (PMID: 25612671).
DPABH-08735 is suitable for use in Western blot (WB) (1:1,000–1:6,000) application.
DPABH-08735 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Transmembrane protein 33; SHINC-3; SHINC3; Protein DB83; DB83

Entrez Gene ID

UniProt ID