Anti-TINCR polyclonal antibody (DPABH-22226)
Rabbit anti-Human TINCR (N-terminal) polyclonal antibody for ICC/IF, WB
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17 amino acid synthetic peptide near the center of Human PLAC2 (AAQ15237).
ICC/IF: 20 μg/ml. WB: 1 - 2 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
TINCR; tissue differentiation-inducing non-protein coding RNA; PLAC2; LINC00036; NCRNA00036
TINCR (Tissue Differentiation-Inducing Non-Protein Coding RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. This gene produces a spliced long non-coding RNA that is required for normal epidermal differentiation. This transcript regulates the expression of genes involved in the differentiation of epidermal tissue. Mutations in some of the genes targeted by this transcript have been implicated in epidermal skin diseases.
This locus is inferred to be non-protein-coding based on the observations that a) there is no homology support for predicted open reading frames; and b) the location of the longer predicted open reading frame renders the transcript a candidate for nonsense-mediated decay (NMD) as the stop codon is >50 nucleotides upstream of the terminal splice site.
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Kretz, M; et al. TINCR, staufen1, and cellular differentiation. RNA BIOLOGY 10:1597-1601(2013).
Kretz, M; Siprashvili, Z; et al. Control of somatic tissue differentiation by the long non-coding RNA TINCR. NATURE 493:231-U245(2013).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.