TIMM22 is an essential core component of the TIM22 protein insertion complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated, signal-gated hydrophilic high-conductance channel. It forms a twin-pore translocase that uses the membrane potential as an external driving force in 2 voltage-dependent steps.
Pathway
Metabolism of proteins, organism-specific biosystem; Mitochondrial Protein Import, organism-specific biosystem;
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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Saeki, K; Suzuki, H; et al. Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. JOURNAL OF BIOLOGICAL CHEMISTRY 275:31996-32002(2000).
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