TIAM2 (NP_001010927, 527 a.a. ~ 624 a.a) partial recombinant protein with GST tag. The sequence is DVHPEAEQQPGPESGEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDS QSENATIDLNSVLEREFSVQSLTSVVSEECFYETESHG
Conjugate
Unconjugated
Target
Alternative Names
TIAM2; T-cell lymphoma invasion and metastasis 2; STEF; TIAM-2; T-lymphoma invasion and metastasis-inducing protein 2; SIF and TIAM1-like exchange factor;
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.
Pathway
Cell death signalling via NRAGE, NRIF and NADE; G alpha (12/13) signalling events; Metabolism; NRAGE signals death through JNK.
Citations
Publication ()
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