Anti-THRA monoclonal antibody (DCABH-201583)

Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2829
Species Reactivity
Dog, Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to N-terminus human THRA.
Conjugate
Unconjugated

Applications


Application Notes
WB (1:1000) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
THRA; thyroid hormone receptor, alpha; AR7; EAR7; ERBA; CHNG6
Entrez Gene ID
UniProt ID

Product Background


Pathway
Endochondral Ossification; Gene Expression; Generic Transcription Pathway; Neuroactive ligand-receptor interaction;Nuclear Receptor transcription pathway; Nuclear Receptors; Thyroid hormone signaling pathway;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis

CANCER LETTERS

Authors: Yi, Chun-Hui; Zheng, Tongzhang; Leaderer, Derek; Hoffman, Aaron; Zhu, Yong

The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, and relevant biological pathways. However, it is difficult to study the biological involvement of NPAS2 in cancer development, as little is known about its direct transcriptional targets. The aim of the current study is to create a transcriptional profile of genes regulated by NPAS2, using a human binding ChIP-on-chip analysis of NPAS2 in MCF-7 cells. This genome-wide mapping approach identified 26 genes that contain potential NPAS2 binding regions. Subsequent real-time PCR assays confirmed 16 of these targets, and 9 of these genes (ARHGAP29, CDC25A, CDKN2AIP, CX3CL1. ELF4, GNAL, KDELR1, POU4F2, and THRA) have a known role in tumorigenesis. In addition, a networking analysis of these validated NPAS2 targets revealed that all nine genes, together with REN, are involved in a "Cancer, Cell cycle, Neurological Disease" network. These results report the first list of direct transcriptional targets of NPAS2 and will shed light on the role of circadian genes in tumorigenesis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Bio-based production of the platform chemical 1,5-diaminopentane

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Authors: Kind, Stefanie; Wittmann, Christoph

In the rising era of bio-economy, the five carbon compound 1,5-diaminopentane receives increasing interest as platform chemical, especially as innovative building block for bio-based polymers. The vital interest in bio-based supply of 1,5-diaminopentane has strongly stimulated research on the development of engineered producer strains. Based on the state-of-art knowledge on the pathways and reactions linked to microbial 1,5-diaminopentane metabolism, the review covers novel systems metabolic engineering approaches towards hyper-producing cell factories of Corynebacterium glutamicum or Escherichia coli. This is integrated into the whole value chain from renewable feedstocks via 1,5-diaminopentane to innovative biopolymers involving bioprocess engineering considerations for economic supply.

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