Anti-THOC2 polyclonal antibody (DPABH-23876)

Rabbit anti-Human THOC2 (aa 1543-1593) polyclonal antibody for WB, IP

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide, corresponding to a region within amino acids 1543-1593 of Human THOC2 (NP_001075019.1).
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 1/500 - 1/2000; WB: 1/2000 - 1/10000; IP: 2-10 μg/mg lysate.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
THOC2; THO complex 2; THO2; CXorf3; hTREX120; dJ506G2.1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
THOC2 (THO Complex 2) is a Protein Coding gene. Diseases associated with THOC2 include mental retardation, x-linked 12/35 and peliosis hepatis. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include RNA binding. The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.
Antigen Description
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4. Mental retardation, X-linked 12 (MRX12) [MIM:300957]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX12 patients manifest variable degrees of intellectual disability. Commonly observed features included speech delay, elevated BMI, short stature, seizure disorders, gait disturbance, and tremors. Note=The disease is caused by mutations affecting the gene represented in this entry. THO complex subunit 2 is a protein that in humans is encoded by the THOC2 gene. 0The function about THOC2 antigen include RNA binding; protein binding.
Pathway
RNA transport; Spliceosome; THC complex; TREX complex.

Citations


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References


SAOUDI, A; CASTEDO, M; et al. SELF-REACTIVE ANTICLASS-II T-HELPER TYPE-2 CELL-LINES DERIVED FROM GOLD SALT-INJECTED RATS TRIGGER B-CELL POLYCLONAL ACTIVATION AND TRANSFER AUTOIMMUNITY IN CD8-DEPLETED NORMAL SYNGENEIC RECIPIENTS. EUROPEAN JOURNAL OF IMMUNOLOGY 25:1972-1979(1995).
Hizawa, N; Freidhoff, LR; et al. Genetic regulation of Dermatophagoides pteronyssinus-specific IgE responsiveness: A genome-wide multipoint linkage analysis in families recruited through 2 asthmatic sibs. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 102:436-442(1998).

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