TGFBRAP1 (transforming growth factor, beta receptor associated protein 1) is a protein-coding gene. Diseases associated with TGFBRAP1 include t cell deficiency, and hepatitis c. GO annotations related to this gene include transforming growth factor beta receptor binding and SMAD binding. An important paralog of this gene is VPS39. Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
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