Anti-TFRC monoclonal antibody, clone DZ-UGS

Antibody Isotype

IgG1

Clone

DZ-UGS

Species Reactivity

Human

Immunogen

Purified human TFRC/TFR2.

Conjugate

Alternative Names

TFRC; transferrin receptor (p90, CD71); transferrin receptor protein 1; CD71; TFR1; T9; TR; TFR; p90; TRFR;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Pathway

Clathrin derived vesicle budding, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem;