Anti-TFAP2A (N-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment (proprietary-tag) within Human AP2 alpha (N terminal). The exact sequence is proprietary.Database link: P05549

Conjugate

Application Notes

WB: 1/1000 - 1/3000;

Alternative Names

TFAP2A; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); AP-2; BOFS; AP2TF; TFAP2; AP-2alpha; transcription factor AP-2-alpha; AP2-alpha; activator protein 2; AP-2 transcription factor; activating enhancer-binding protein 2-a

Entrez Gene ID

UniProt ID

Antigen Description

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.

Pathway

Caspase cascade in apoptosis; Neural Crest Differentiation;