Anti-TECTA monoclonal antibody (DCABH-693)

Mouse anti-Human TECTA monoclonal antibody for WB, ELISA, sELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Species Reactivity
Human
Immunogen
Recombinant fragment corresponding to amino acids 1981-2081 of Human TECTA (NP_005413), with proprietary tag. Mol wt 37.11 kDa inclusive of tag.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 - 5 μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TECTA; tectorin alpha; DFNA8, DFNA12, DFNB21; alpha-tectorin; DFNA8; DFNA12
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TECTA (Tectorin Alpha) is a Protein Coding gene. Diseases associated with TECTA include deafness, autosomal dominant 8/12 and deafness, autosomal recessive 21. An important paralog of this gene is OTOG. The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.
Antigen Description
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Deafness, autosomal dominant, 12 (DFNA12) [MIM:601543]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations affecting the gene represented in this entry. Deafness, autosomal recessive, 21 (DFNB21) [MIM:603629]: A form of non-syndromic sensorineural hearing loss. Alpha-tectorin is a protein that in humans is encoded by the TECTA gene. 0The function about TECTA antigen include extracellular matrix structural constituent.

Citations


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References


Williams, DK; GannonMurakami, L; et al. Polysialylated neural cell adhesion molecule and plasticity of ipsilateral connections in Xenopus tectum. NEUROSCIENCE 70:277-285(1996).
Dreiling, FJ; Henson, MM; et al. The presence and arrangement of type 11 collagen in the basilar membrane. HEARING RESEARCH 166:166-180(2002).

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