Anti-TCTN2 monoclonal antibody (DCABH-936)

Mouse anti-Human TCTN2 monoclonal antibody for WB, FC, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2D2
Species Reactivity
Human
Immunogen
Recombinant full length Human TCTN2 produced in HEK293T cells (NP_079085).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/500; Flow Cyt: 1/100; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TCTN2; tectonic family member 2; C12orf38, chromosome 12 open reading frame 38; tectonic-2; FLJ12975; Meckel syndrome
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TCTN2 (Tectonic Family Member 2) is a Protein Coding gene. Diseases associated with TCTN2 include meckel syndrome 8 and joubert syndrome 1. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Antigen Description
This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Joubert syndrome 24 (JBTS24) [MIM:616654]: A form of Joubert syndrome, a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy, renal disease, liver fibrosis, and polydactyly. Note=The disease is caused by mutations affecting the gene represented in this entry. Meckel syndrome 8 (MKS8) [MIM:613885]: A disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly.

Citations


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References


Martin, RF; et al. A-type granites of crustal origin ultimately result from open-system fenitization-type reactions in an extensional environment. LITHOS 91:125-136(2006).
Shih, HT; Yeo, DCJ; et al. The collision of the Indian plate with Asia: molecular evidence for its impact on the phylogeny of freshwater crabs (Brachyura: Potamidae). JOURNAL OF BIOGEOGRAPHY 36:703-719(2009).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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