Anti-TCR gamma + TCR delta monoclonal antibody, clone VD8-24E6 [Biotin]

Antibody Isotype

IgG

Clone

VD8-24E6

Species Reactivity

Mouse

Immunogen

The details of the immunogen for this antibody are not available.

Conjugate

Application Notes

Flow Cyt: 0.3μg/10⁶ cells.

Alternative Names

CD3D; CD3 antigen, delta polypeptide; T-cell surface glycoprotein CD3 delta chain; T-cell receptor T3 delta chain; T3d;

Entrez Gene ID

UniProt ID

Antigen Description

T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one a and one b chain or one d and one g chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. The g/d TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most g/d T cells are CD4-/CD8-, some are CD8+. T cells expressing the g/d TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease.

Pathway

Adaptive Immune System, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Downstream TCR signaling, organism-specific biosystem; Generation of second messenger molecules, organism-specific biosystem; HTLV-I infection, organism-specific biosystem;