Anti-TCP1 (full length) polyclonal antibody

Species Reactivity

Human

Immunogen

TCP1 (AAH00665, 1 a.a. ~ 556 a.a) full-length recombinant protein with GST tag. The sequence is MEGPLSVFGDRSTGETIRSQNVMAAASIANIVKSSFGPVGLDKMLVDDIGDVTITNDGAT ILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISG YRLACKEAVRYINENLIVNTDELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAIK YTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYALNCVVGSQGMPKRIVNAKIACLDFS LQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYF VEAGAMAVRRVLKRDLKRIAKASGATILSTLANLEGEETFEAAMLGQAEEVVQERICDDE LILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLE

Conjugate

Alternative Names

TCP1; t-complex 1; CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha; T-complex protein 1 subunit alpha; tailless complex polypeptide 1; T-complex protein 1, alpha subunit;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.

Pathway

Association of TriC/CCT with target proteins during biosynthesis; Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC