Anti-TCHH polyclonal antibody (DPABH-24159)

Rabbit anti-Human TCHH (aa 1800-1900) polyclonal antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1800 - 1900 of Human Trichohyalin.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TCHH; trichohyalin; THH; THL; TRHY
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TCHH (Trichohyalin) is a Protein Coding gene. Diseases associated with TCHH include inflamed seborrheic keratosis and superficial urinary bladder cancer. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is TCHHL1. Trichohyalin confers mechanical strength to the hair follicle inner root sheath and to other toughened epithelial tissues, such as the hard palate and filiform ridges of the tongue, by forming multiple complex crosslinks with itself and with other structural proteins (Steinert et al. , 2003 [PubMed 12853460]).
Antigen Description
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. The function about TCHH antigen include calcium ion binding.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Alibardi, L; et al. Keratinization in crocodilian scales and avian epidermis: evolutionary implications for the origin of avian apteric epidermis. BELGIAN JOURNAL OF ZOOLOGY 135:9-20(2005).
Nishizawa, M; Izawa, I; et al. Identification of trichoplein, a novel keratin filament-binding protein. JOURNAL OF CELL SCIENCE 118:1081-1090(2005).

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