Anti-TCF7L2 (aa 1-100) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse

Immunogen

Fusion protein: MPQLNGGGGD DLGANDELIS FKDEGEQEEK NSENSSAERD LADVKSSLVN ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY, corresponding to amino acids 1/100 of Mouse T cell Transcription Factor 4

Conjugate

Application Notes

WB: 1/1000;

Alternative Names

TCF7L2; transcription factor 7 like 2, T cell specific, HMG box; transcription factor 7-like 2; mTCF-4; T-cell factor 4; HMG box transcription factor 4; T-cell-specific transcription factor 4; transcription factor 7-like 2, T-cell specific, HMG-box; Tcf4;

Entrez Gene ID

UniProt ID

Antigen Description

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5-CCTTTGATC-3 in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Pathway

Acute myeloid leukemia; Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Basal cell carcinoma;