Anti-TCF7L2 (aa 490-596) polyclonal antibody

Species Reactivity

Human

Immunogen

TCF7L2 (NP_110383, 490 a.a. ~ 596 a.a) partial recombinant protein with GST tag. The sequence is SPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKASALCPNGA LDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGTQPQPLSLVTKSLE

Conjugate

Alternative Names

TCF7L2; transcription factor 7-like 2 (T-cell specific, HMG-box); TCF4; TCF-4; transcription factor 7-like 2; hTCF-4; T-cell factor 4; T-cell factor-4 variant A; T-cell factor-4 variant B; T-cell factor-4 variant C; T-cell factor-4 variant D; T-cell facto

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Pathway

Acute myeloid leukemia; Arrhythmogenic right ventricular cardiomyopathy; Basal cell carcinoma; Colorectal cancer