Anti-TBX4 monoclonal antibody, clone 8C22

Clone

8C22

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human TBX5.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000) & The optimal working dilution should be determined by the end user.

Alternative Names

TBX5; T-box 5; HOS; T-box transcription factor TBX5; T-box protein 5;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

Pathway

Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Heart Development, organism-specific biosystem; YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem;