Rabbit Anti-Human TBP Polyclonal antibody

ab]Abstract A unified model based on published data and authors' experimental results was suggested for describing the extraction of An(VI) (An = U, Np, Pu, Am) from HNO3 solutions into TBP solutions of various concentrations. Parallel occurrence of several extraction reactions and of nonstoichiometric physicochemical interaction of the components is assumed. The calculated parameters of the dependence of the concentration equilibrium constants on the total TBP concentration allowed expansion of the range of extractant concentrations described by the model (from 2.7 to 100%) and reduction of the uncertainty in calculation of the HNO3 and An(VI) distribution ratios. The parameter of apparent hydration of nitrate salt cations in the aqueous phase was used for describing the salting-out effect of these salts.

Tick-borne pathogens (TBP) are a major source of production loss and a welfare concern in livestock across the globe. Consequently, there is a trade-off between keeping animals that are tolerant to TBP infection, but are less productive than more susceptible breeds. Theileria annulata is a major TBP of bovines, with different host types (i.e. exotic and native cattle breeds, and buffalo) displaying demonstrable differences in clinical susceptibility to infection. However, the extent to which these differences are driven by genetic/physiological differences between hosts, or by different parasite populations/genotypes preferentially establishing infection in different host breeds and species is unclear. In this study, three different bovine host types in India were blood sampled to test for the presence of various TBP, including Theileria annulata, to determine whether native cattle (Bos indicus breeds), crossbreed cattle (Bos taunts x Bos indicus breeds) or water buffalo (Bubalus bubalis) differ in the physiological consequences of infection. Population genetic analyses of T. annulata isolated from the three different host types was also performed, using a panel of mini- and micro-satellite markers, to test for sub-structuring of the parasite population among host types. We discovered that compared to other host types, "carrier" crossbreed cattle showed a higher level of haematological pathology when infected with T. annulata. Despite this finding, we found no evidence for differences in the genotypes of T. annulata infecting different host types, although buffalo appeared to harbour fewer mixed parasite genotype infections, indicating they are not the major reservoir of parasite diversity. The apparent tolerance/resistance of native breed cattle and buffalo to the impacts of T. annulata infection is thus most likely to be driven by host genotype, rather than differences in the parasite population. Our results suggest that an improved understanding of the genetic factors that underpin disease resistance could help to ameliorate future economic loss due to TBP or tropical theileriosis.