Anti-TBP (aa 227-339) polyclonal antibody

Species Reactivity

Human

Immunogen

TBP (NP_003185, 227 a.a. ~ 339 a.a) partial recombinant protein with GST tag. The sequence is EEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPE LFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT

Conjugate

Alternative Names

TBP; TATA box binding protein; HDL4; GTF2D; SCA17; TFIID; GTF2D1; TATA-box-binding protein; TATA-box factor; TATA sequence-binding protein; TATA-box binding protein N-terminal domain; transcription initiation factor TFIID TBP subunit;

Entrez Gene ID

UniProt ID

Antigen Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.

Pathway

Basal transcription factors; Disease; Epstein-Barr virus infection; Eukaryotic Transcription Initiation