General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
Pathway
Basal transcription factors; Disease; Epstein-Barr virus infection; Eukaryotic Transcription Initiation; Gene Expression; Glucocorticoid receptor regulatory network; HIV Infection; HIV Life Cycle;
Citations
Publication ()
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References
The extraction of gallium from chloride solutions by emulsion liquid membrane: Optimization through response surface methodology
Emulsion liquid membrane was used to extract gallium from a chloride medium. The influence of several critical parameters including, carrier concentration, surfactant concentration, the ratio of the internal phase to the membrane, agitation speed and their interactions on gallium recovery were investigated. A response surface methodology based on a Box-Behnken design was used to find out optimum conditions and determine the interaction effects of parameters. The liquid membrane including a diluent (kerosene), a surfactant (sorbitan monooleate), a carrier (tri-isobutyl phosphate), and 0.1 M sulfuric acid as the stripping solution was used. Maximum gallium recovery (94.6%) were obtained at the carrier concentration of 5.8% (v/v), the surfactant concentration of 3.2% (v/v), the ratio of the internal phase to the membrane of 1.1 and the agitation speed of 245 rpm. The gallium recovery increased with an increase in the level of the investigated parameters, and after reaching the optimum conditions, it decreased. A predictive model was proposed to predict the gallium recovery from the chloride solution by emulsion liquid membrane. The results indicated that the gallium can be effectively recovered from the chloride solution using emulsion liquid membrane with tri-butyl phosphate (TBP) as a carrier.
Predicting medical tourism behavioural intention using social cognition models
Purpose - Few studies have adopted social psychology theories to understand the medical tourism decision-making process. The purpose of this study is to fill the said gap by suggesting the adoption of two social cognition models: the theory of planned behaviour (TPB) and protection motivation theory (PMT), to predict medical tourism behavioural intention, as well as compare their predictive power by integrating TBP and PMT in a single model. Design/methodology/approach - A quantitative method has been adopted. There were 265 international tourists from various regions who visited Malaysia (one of the main medical tourism players in Asia), who were asked to complete the survey questionnaire. Data was analysed using the partial least squares structural equation modelling technique. Findings - The results of this study provided support and validated the well-developed research models of TPB and PMT. Although PMT appears to be a more concrete and specific framework, the TPB model results have a slight advantage. TPB results emphasised the important roles of attitude, subjective norms and perceived behavioural control in developing behavioural intentions, and thus directly linked to the development of pull marketing strategies. PMT results emphasised the important roles of perceived threats and coping appraisal of health care in developing push strategies for medical tourism. Originality/value - The research illustrates the need for rigorous examination of the ability of behavioural theories. The findings can aid in scrutinising their shortcomings and their readiness to modify, integrate and enhance in a more constructive manner when they address the health-education interventions, especially in a medical tourism context.