Anti-TBL1XR1 monoclonal antibody, clone 5G4-B9-E0

Antibody Isotype

IgG1

Clone

5G4-B9-E0

Species Reactivity

Mouse; Human

Immunogen

Recombinant full length Human TBLR1 protein

Conjugate

Application Notes

WB: 1/100 - 1/2000; ELISA: 1/5000 - 1/20000; IHC-P: 1/500 - 1/1000; ICC: 1/150.

Alternative Names

TBL1XR1; transducin (beta)-like 1 X-linked receptor 1; transducin (beta) like 1X linked receptor 1; F-box-like/WD repeat-containing protein TBL1XR1; C21; DC42; FLJ12894; IRA1; TBLR1; TBL1-related protein 1; transducin beta-like 1X-related protein 1; nucle

Entrez Gene ID

UniProt ID

Antigen Description

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

Pathway

BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem;