This product (Catalog No. DPABH-20132) is a rabbit-derived polyclonal antibody raised against human TAX1BP1, targeting the amino acid region 454–789 of the protein. It has been affinity purified by Protein A. TAX1BP1 (also named as T6BP and TXBP151) inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. It is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. TAX1BP1 binds TRAF6 but not TRAFs 1-5. DPABH-20132 is suitable for use in Western blot (WB) (1:1,000–1:5,000), IHC (1:250–1:1,000), IF/ICC (1:200–1:800) applications. DPABH-20132 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Target
Alternative Names
TRAF6-binding protein; Tax1-binding protein 1; T6BP; PRO0105
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