Anti-TAX1BP1 (aa 690-789) polyclonal antibody

Species Reactivity

Human

Immunogen

TAX1BP1 (NP_006015, 690 a.a. ~ 789 a.a) partial recombinant protein with GST tag. The sequence is DSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEH VESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD

Conjugate

Alternative Names

TAX1BP1; Tax1 (human T-cell leukemia virus type I) binding protein 1; T6BP; TXBP151; CALCOCO3; tax1-binding protein 1; TRAF6-binding protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Pathway

Immune System; Negative regulators of RIG-I/MDA5 signaling;