The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners (Max et al., 2001 [PubMed 11326277]).[supplied by OMIM, Jan 2010]
Pathway
Carbohydrate digestion and absorption; Class C/3 (Metabotropic glutamate/pheromone receptors); Signal Transduction; Taste transduction.
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