Anti-TACR2 monoclonal antibody (DCABH-1712)

Rabbit anti-Human TACR2 monoclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS7949(C)
Species Reactivity
Mouse, Rat, Human
Immunogen
Synthetic peptide, corresponding to residues in Human Neurokinin A Receptor.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TACR2; tachykinin receptor 2; NKNAR, TAC2R; substance-K receptor; NK2R; SKR
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TACR2 (Tachykinin Receptor 2) is a Protein Coding gene. Diseases associated with TACR2 include asthma. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and substance K receptor activity. An important paralog of this gene is NPY1R. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.
Antigen Description
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Substance-K receptor is a protein that in humans is encoded by the TACR2 gene. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. The function about TACR2 antigen include G-protein coupled receptor activity; receptor activity; signal transducer activity; tachykinin receptor activity.
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem.

Citations


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References


Tripp, RA; Moore, D; et al. Respiratory syncytial virus infection and G and/or SH protein expression contribute to substance P, which mediates inflammation and enhanced pulmonary disease in BALB/c mice. JOURNAL OF VIROLOGY 74:1614-1622(2000).
CUMBERBATCH, MJ; CHIZH, BA; et al. MODULATION OF EXCITATORY AMINO-ACID RESPONSES BY TACHYKININS AND SELECTIVE TACHYKININ RECEPTOR AGONISTS IN THE RAT SPINAL-CORD. BRITISH JOURNAL OF PHARMACOLOGY 115:1005-1012(1995).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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