This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Pathway
Calcium signaling pathway; Class A/1 (Rhodopsin-like receptors); GPCR downstream signaling; Gastrin-CREB signalling pathway via PKC and MAPK
Citations
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