TACR1 (NP_001049, 140 a.a. ~ 243 a.a) partial recombinant protein with GST tag. The sequence is PRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHIC VTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAK
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
Pathway
Calcium signaling pathway; Class A/1 (Rhodopsin-like receptors); GPCR downstream signaling; Gastrin-CREB signalling pathway via PKC and MAPK
Citations
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