Anti-TCF4 monoclonal antibody, clone 7G23-4

Antibody Isotype

IgG1

Clone

7G23-4

Species Reactivity

Human; Mouse

Immunogen

Produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with a His-tagged fusion protein corresponding to amino acids 31-331 of Human TCF4.

Conjugate

Application Notes

Recommended concentration:
WB: 1-4 μg/mL

Alternative Names

TCF4; transcription factor 4; MITF-2; SL3-3 enhancer factor 2; immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; class A helix-loop-helix transcription factor ME2; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); ME2; TFE

Entrez Gene ID

UniProt ID

Antigen Description

T-cell factor 3 and 4 (TCF3 and TCF4) are transcription factors of the High Mobility Group of DNA binding proteins. They are members of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer. TCF4 generates transcriptionally active complexes with beta catenin in colon carcinoma cells. TCF3 appears to be expressed independently of TCF4 in the hair follicles, stomach epithelium, and keratinocytes of the skin.

Pathway

CDO in myogenesis, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Myogenesis, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem.