Anti-Radial Nerve Cord Extract monoclonal antibody (DMAB9345)

Mouse anti-Holothuria Radial Nerve Cord Extract monoclonal antibody for WB, IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
ERG2
Species Reactivity
Holothuria
Immunogen
Radial nerve cord extract from sea cucumber Holothuria glaberrima (Echinodermata: Holothuroidea).
Conjugate
Unconjugated

Target


Alternative Names
Radial nerve cord extract

Product Background


Antigen Description
Many metazoan neuropeptides are amidated at their C-terminal end and this amidation appears to be critical for the biological activity of the neuropeptide. The only enzyme known to catalyse this important posttranslational modification is peptidylglycine α-amidating monooxygenase (PAM). PAM is a bifunctional enzyme made of two subunits: the peptidylglycine α-hydroxylating monooxygenase (PHM), requiring copper for its action, and the peptidyl- α-hydroxyglycine α-amidating lyase (PAL). In this study, we investigated the presence PAM-like enzymatic activity in an echinoderm. Extracts from radial nerve cords of the sea star Asterias rubens were incubated in vitro with fluorescent peptide substrata in the presence or absence of Cu ++. The results demonstrate a Cu++ -dependent amidation activity similar to the PAM action in other metazoans.

Citations


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References


Lois, C; GarciaVerdugo, JM; et al. Chain migration of neuronal precursors. SCIENCE 271:978-981(1996).
Ji, M; Zhao, WJ; et al. RGS2 and RGS4 modulate melatonin-induced potentiation of glycine currents in rat retinal ganglion cells. BRAIN RESEARCH 1411:1-8(2011).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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