Anti-SYT2 monoclonal antibody (CAB-4803MH)

Mouse anti-SYT2 monoclonal antibody for ELISA, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
MAAG2250
Species Reactivity
Human
Immunogen
SYT2 (NP_796376, 311 a.a - 419 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SYT2; synaptotagmin II; synaptotagmin-2; synaptotagmin 2; SytII; FLJ42519
Entrez Gene ID
UniProt ID

Product Background


Gene summary
SYT2 (Synaptotagmin 2) is a Protein Coding gene. Diseases associated with SYT2 include myasthenic syndrome, congenital, 7, presynaptic and presynaptic congenital myasthenic syndromes. Among its related pathways are Infectious disease and Uptake and actions of bacterial toxins. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT5. This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants.
Antigen Description
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Myasthenic syndrome, congenital, 7, presynaptic (CMS7) [MIM:616040]: A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS7 is an autosomal dominant, presynaptic disorder resembling Lambert-Eaton myasthenic syndrome. Affected individuals have a variable degree of proximal and distal limb weakness, muscle fatigue that improves with rest, mild gait difficulties, and reduced or absent deep tendon reflexes. Note=The disease is caused by mutations affecting the gene represented in this entry. Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene. 0The function about SYT2 antigen include metal ion binding; protein binding; transporter activity.
Pathway
Botulinum neurotoxicity, organism-specific biosystem; Disease, organism-specific biosystem; Neuronal System, organism-specific biosystem; Translocation of BoNT Light chain, organism-specific biosystem.

Citations


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References


Monterrat, C; Boal, F; et al. Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1763:73-81(2006).
Neumann, S; Haverkamp, S; et al. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2. JOURNAL OF COMPARATIVE NEUROLOGY 521:709-724(2013).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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