Anti-SYN2 monoclonal antibody (CAB-4797RH)

Rabbit anti-SYN2 monoclonal antibody for WB, FC, IHC, ICC Datasheet

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Specifications


Host Species
Rabbit
Clone
MAAG2244
Species Reactivity
Human, Mouse, Rat
Immunogen
SYMPK (AAH30214, 1 a.a. - 534 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:5000-10000; IHC: 1:100-250
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SYN2; synapsin II; synapsin-2; SYNII; SYNIIa; SYNIIb
Entrez Gene ID
UniProt ID
Q92777

Product Background


Gene summary
SYN2 (Synapsin II) is a Protein Coding gene. Diseases associated with SYN2 include schizophrenia. Among its related pathways are Neurotransmitter Release Cycle and Transmission across Chemical Synapses. An important paralog of this gene is SYN3. This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction.
Antigen Description
Synapsin II is the collective name for synapsin IIa and synapsin IIb, two nearly identical phosphoproteins in the synapsin family that in humans are encoded by the SYN2 gene. Synapsins associate as endogenous substrates to the surface of synaptic vesicles and act as key modulators in neurotransmitter release across the presynaptic membrane of axonal neurons in the nervous system. Synapsin II regulates synaptic function of neurons in the central and peripheral nervous system. Synapsin IIa is the only synapsin isoform of the six synapsin isoforms (synapsin I-III each with isoforms A and B), which has been shown to significantly reverse synaptic depression and have a restorative effect on the density of synaptic vesicles within synapsinless neurons. Because of its restorative effect, synapsin IIa is believed to play a fundamental role in synaptic vesicle mobilization and reserve pool regulation in presynaptic nerve terminals.
Pathway
Dopamine Neurotransmitter Release Cycle, organism-specific biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter Release Cycle, organism-specific biosystem; Serotonin Neurotransmitter Release Cycle, organism-specific biosystem; Transmission across Chemical Synapses, organism-specific biosystem.

Citations


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References


Halden, Y; Rek, A; et al. Interleukin-8 binds to syndecan-2 on human endothelial cells. BIOCHEMICAL JOURNAL 377:533-538(2004).
Nagai, R; Hashimoto, R; et al. Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology. EXPERIMENTAL CELL RESEARCH 316:2313-2321(2010).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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